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Doctors in training cyp450 inducer8/2/2023 ![]() This will mean that the patient will be at an increased risk of DVT, PE etc. This means that the plasma concentration of warfarin will decrease, meaning that the INR will decrease (as the anticoagulant effect of warfarin is lessened). warfarin is metabolised (into an inactive compound) by this enzyme, then warfarin will be metabolised more quickly under the influence of rifampicin. rifampicin = a drug that stimulates the production of a CYP450 enzyme, e.g. P450 inducers stimulate metabolism, say for example they are co-administered with warfarin, does this mean that they will make warfarin less potent and increase the risk of DVT? Hello, I hope you wont mind clarifying this for me please
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